Why the study?
What is the pharmacokinetic profile and haemodynamic response of intravenous nitroglycerin in patients with congestive cardiac failure?
Population
10 patients with congestive cardiac failure
Design
Cohort
Follow-up
duration of infusion
Authors
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GTN infusion achieves rapid steady-state haemodynamics in heart failure; extends pharmacokinetic data but leaves optimal titration strategies open for prospective trials.
What is the pharmacokinetic profile and haemodynamic response of intravenous nitroglycerin in patients with congestive cardiac failure?
Intravenous nitroglycerin in heart failure patients achieves steady state concentration and maximal haemodynamic effects (reductions in filling pressures) rapidly, with closely matching time constants of approximately 8-10 minutes.
Armstrong et al. (1983) studied this question.
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