Abnormal Rheologic Effects of Glyceryl Trinitrate in Patients with Non-Insulin-Dependent Diabetes Mellitus and Reversal by Antioxidants

80 subjects: 40 patients with non-insulin-dependent diabetes mellitus and no evidence of cardiovascular complications, and 40 controls matched for demographic variables and body habitus.

Sublingual glyceryl trinitrate (0.3 mg) and transdermal glyceryl trinitrate patches (10 mg/d), with antioxidant supplementation (Vitamin E 300 mg/d orally for 7 days, and glutathione 600 mg intravenously or intramuscularly) to test reversal of effects.

Healthy controls matched for demographic variables and body habitus receiving the same interventions.

Hemorrheologic and hemodynamic effects (platelet aggregation, blood viscosity, blood filterability, blood pressure, heart rate, left ventricular ejection fraction).surrogate