⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

May 1, 1983American Review of Respiratory Disease

The Effects of the Nude (nu/nu) Mutation on Bleomycin-induced Pulmonary Fibrosis

View Full Paper

Ask AI

Bookmark

Share

Key Points

This study aims to investigate how the nude mutation affects the development of pulmonary fibrosis induced by bleomycin in mice.
Mice with nude mutation and euthymic controls were treated with a single intratracheal instillation of bleomycin (0.75 units/animal).
Histological examinations and measurements of total lung hydroxyproline and collagen synthesis were performed at 14 and 30 days post-treatment.
Histological analysis showed reduced cellular infiltration and fibroblast proliferation in nude mice compared to euthymic controls.
Total lung hydroxyproline levels were not significantly elevated in nude mice after bleomycin treatment at both 14 and 30 days.
Lung collagen synthesis was significantly higher in euthymic mice compared to nude mice at 14 days, indicating a protective role of the nude mutation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Randomized trial evaluates nude mutation impact on pulmonary fibrosis in mice, indicating immune system involvement.

Cite This Study

Schrier et al. (1983) studied this question.

synapsesocial.com/papers/6a18ff9bacdd6f4dc9d31032 https://doi.org/10.1164/arrd.1983.127.5.614

View Full Paper

Ask AI

Bookmark

Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Bleomycin promotes cellular senescence and activation of the cGAS-STING pathway without direct effect on fibrosis in an idiopathic pulmonary fibrosis model2025 · 1 citations
2Relationships between Early Inflammatory Response to Bleomycin and Sensitivity to Lung Fibrosispreclinical · 2007 · 21 citations
3Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in micepreclinical · 2017 · 48 citations
4A74-42 NF-kB Signaling Promotes Epithelial Organoid Formation But Does Not Alter Bleomycin-induced FibrosisOriginal Research · 2026
5Optimization of intranasal bleomycin dose for effective pulmonary fibrosis induction in mice with minimal animal distress2025 · 1 citations