Key result
Atrial natriuretic peptide significantly decreased lung fibrotic area and infiltration of inflammatory cells in mice with bleomycin-induced pulmonary fibrosis.
Why the study?
Does ANP prevent lung fibrosis and inflammation in a mouse model of bleomycin-induced pulmonary fibrosis?
Does ANP prevent lung fibrosis and inflammation in a mouse model of bleomycin-induced pulmonary fibrosis?
p-value: p=<0.05
ANP exerts protective anti-fibrotic and anti-inflammatory effects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice.
No takes yet. Share an insight, caveat, or question.
ANP may warrant exploration as a fibrosis therapy; animal data leave open human translation and should not yet change practice.
Okamoto et al. (2017) studied Bleomycin-induced pulmonary fibrosis (n=60). Atrial natriuretic peptide (ANP) vs. Vehicle was evaluated on Lung fibrotic area (p=<0.05). Atrial natriuretic peptide significantly decreased lung fibrotic area and infiltration of inflammatory cells in mice with bleomycin-induced pulmonary fibrosis.
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