Prognostic impact of outpatient loop diuretic reduction patterns in patients with chronic heart failure

Fig. 1. Example of successive loop diuretic dose reduction pattern. Successive dose reduction is defined as ≥ 2 successive loop diuretic (LD) dose reductions without intervening LD dose intensification. This graph shows the actual time course of LD dose in patients included in the present study. Example 1, discontinuation of LDs after 3 successive dose reductions without intervening LD dose intensification. Example 2, the first dose reduction is not successive, but the second dose reduction involves 2 successive LD dose reductions without intervening LD dose intensification.

Fig. 2. Example of single loop diuretic reduction pattern. Single dose reduction is defined as loop diuretic (LD) dose reduction without successive dose reduction during the follow-up period. This graph shows the actual time course of LD dose in patients included in the present study. Example 1, there is a one-time dose reduction without LD intensification during the follow-up period. Example 2, there are two instances of loop diuretic dose reductions during the follow-up period, with an intervening LD intensification.

Fig. 3. Flowchart of the patient selection process.

Fig. 4. Probability of event free for the clinical outcomes categorized into no reduction and reduction of loop diuretic dose. For patients whose loop diuretic (LD) dose is not reduced (no reduction group), time zero corresponds to the baseline time. For patients whose LD dose is reduced during follow-up (reduction group), time zero corresponds to the first time the LD dose is reduced. The Mantel-Byar test with a Simon-Makuch plot is used to compare the event-free survival rate between the no-reduction and reduction groups. A, All-cause death. B, Cardiovascular death. C, Heart failure hospitalization. D, The composite outcome of heart failure hospitalization and cardiovascular death.

Fig. 5. Probability of event free for the clinical outcome categorized into single and successive reductions of loop diuretic dose. For patients whose loop diuretic (LD) dose is reduced but not successively reduced during the follow-up period (single reduction group), time zero corresponds to the first LD dose reduction time during follow-up. For patients whose LD dose is successively reduced during follow-up (successive reduction group), time zero corresponds to the first time the LD dose is successively reduced during follow-up. The Mantel-Byar test with a Simon-Makuch plot is used to compare the event-free survival rate between the single reduction and successive reduction groups. A, All-cause death. B, Cardiovascular death. C, Heart failure hospitalization. D, The composite outcome of heart failure hospitalization and cardiovascular death

Supplementary Fig. 1.