Key result
Perioperative beta-blockers were evaluated in a systematic review of 88 randomized controlled trials involving 19,161 participants, though specific efficacy results were truncated in the provided text.
Why the study?
Do perioperatively administered beta-blockers reduce surgery-related mortality and morbidity in patients undergoing surgery under general anaesthesia?
Population
19,161 patients from 88 randomized controlled trials undergoing any type of surgery with all or a…
Comparison
Perioperatively administered beta-blockers vs Standard care or placebo
Design
Meta-analysis
Authors
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Raises mortality and stroke risk in non-cardiac surgery; challenges routine use and supports surgery-type-specific recommendations.
Systematic Review (n=19,161)
Do perioperatively administered beta-blockers reduce surgery-related mortality and morbidity in patients undergoing surgery under general anaesthesia?
Perioperative beta-blockers reduce arrhythmias in cardiac surgery but increase mortality and stroke risk in non-cardiac surgery, offsetting their benefits in reducing myocardial infarction.
Blessberger et al. (2018) conducted a systematic review in Surgery under general anaesthesia (n=19,161). Perioperative beta-blockers vs. Standard care or placebo was evaluated on Surgery-related mortality and morbidity. Perioperative beta-blockers were evaluated in a systematic review of 88 randomized controlled trials involving 19,161 participants, though specific efficacy results were truncated in the provided text.
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