Why the study?
Does abnormal glucose tolerance or diabetes predict mortality in patients with acute heart failure?
Population
454 consecutive index emergency heart failure admissions to one University hospital during the year 2000.
Comparison
Abnormal glucose tolerance or diabetes vs Normal admission blood glucose (<8 mmol/l)
Design
Cohort
Follow-up
median 812 (range 632-978) days
Key result
Diabetes predicted long-term mortality (HR 2.02; 95% CI 1.41-2.88; p=0.0001) and abnormal glucose tolerance predicted in-hospital mortality (HR 5.920; p=0.046) in acute heart failure patients.
Authors
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May inform acute HF risk stratification; extends observational data but leaves causal effects open.
Cohort (n=454)
No
Does abnormal glucose tolerance or diabetes predict mortality in patients with acute heart failure?
Effect estimate: HR 2.02 (95% CI 1.41 to 2.88)
Absolute Event Rate: 50% vs 36.6%
p-value: p=0.0001
Admission blood glucose concentration and diabetes are prognostically important in acute heart failure, with abnormal glucose tolerance predicting in-hospital mortality and diabetes predicting long-term mortality.
Berry et al. (2007) conducted a cohort in acute heart failure (n=454). Diabetes vs. Normal admission blood glucose was evaluated on mortality during follow-up (HR 2.02, 95% CI 1.41 to 2.88, p=0.0001). Diabetes predicted long-term mortality (HR 2.02; 95% CI 1.41-2.88; p=0.0001) and abnormal glucose tolerance predicted in-hospital mortality (HR 5.920; p=0.046) in acute heart failure patients.