Key result
Epicardial and perivascular adipose tissue in CVD patients shows ~90% stem cell membrane protein expression.
Why the study?
The study was conducted to evaluate the immunophenotype of adipose tissue stem cells isolated from epicardial and perivascular fat depots in patients with coronary heart disease and acquired heart defects.
Observational
Cells of the stromal vascular fraction isolated from epicardial and perivascular adipose tissue in patients with cardiovascular disease express surface markers characteristic of adipose tissue stem cells.
May identify stem cell sources in cardiac adipose tissue; leaves open therapeutic potential pending functional studies.
Aim: to evaluate the immunophenotype of adipose tissue stem cells isolated from epicardial and perivascular fat depots in patients with coronary heart disease and acquired heart defects. Results: In cell culture obtained from epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT) (2nd passage) in patients with both coronary heart disease and acquired heart defects, a high (over 90%) expression of membrane proteins characteristic of stem cells. In addition to the main population, with both in the EAT culture and in the PVAT, there were 2 minor ones: 1 – CD90-, CD105+, CD34-/+, CD73+, CD45- is presumably endothelial population, 2 – CD90+, CD105-, CD34-, CD73-, CD45- is the smallest population. Conclusion: In the early stages of cultivation, cells of the stromal vascular fraction isolated from epicardial and perivascular adipose tissue express surface markers characteristic of adipose tissue stem cells.
No takes yet. Share an insight, caveat, or question.
Учасова et al. (2023) conducted an observational in Coronary heart disease and acquired heart defects. Cell culture from epicardial and perivascular adipose tissue was evaluated on Expression of membrane proteins characteristic of stem cells. Cell cultures from epicardial and perivascular adipose tissue in patients with cardiovascular diseases showed high (>90%) expression of membrane proteins characteristic of stem cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: