Key result
The MADIT-RIT trial is designed to enroll 1500 patients to determine if high rate cutoff or long delay programming in ICD/CRT-D devices reduces inappropriate therapies compared to standard programming.
Why the study?
Does dual-chamber ICD or CRT-D devices with high rate cutoff and/or long delay reduce inappropriate therapies in patients with indication for primary prevention device therapy?
Population
Planned 1500 patients with indication for primary prevention device therapy
Comparison
Dual-chamber ICD or CRT-D devices with high rate… vs Standard programming (MADIT-RIT-Arm A)
Design
Other, randomized, three-arm, nonblinded
Authors
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Optimal ICD programming to reduce inappropriate therapies remains untested; MADIT-RIT will deliver first randomized evidence.
RCT (n=1,500)
Open-label
Randomized
Yes
Does dual-chamber ICD or CRT-D devices with high rate cutoff and/or long delay reduce inappropriate therapies in patients with indication for primary prevention device therapy?
The MADIT-RIT trial protocol outlines a randomized study to evaluate whether high rate cutoff or long delay programming reduces inappropriate ICD therapies in primary prevention patients.
Schuger et al. (2012) conducted an RCT in Indication for primary prevention device therapy (n=1,500). Dual-chamber ICD or CRT-D devices with high rate cutoff and/or long delay vs. Standard programming was evaluated on Inappropriate therapies. The MADIT-RIT trial is designed to enroll 1500 patients to determine if high rate cutoff or long delay programming in ICD/CRT-D devices reduces inappropriate therapies compared to standard programming.
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