Key result
Higher triglyceride levels increased the risk of first ischaemic stroke in elderly hypertensive patients, with the highest quartile showing an HR of 1.85 (95% CI 1.05 to 2.89; p=0.002 for trend).
Why the study?
Although hyperlipidaemia is a known risk factor for ischaemic stroke, the association between triglyceride levels and first ischaemic stroke remains uncertain.
Do higher triglyceride levels increase the risk of first ischaemic stroke in elderly hypertensive patients?
Cohort (n=3,249)
No
Do higher triglyceride levels increase the risk of first ischaemic stroke in elderly hypertensive patients?
Effect estimate: HR 1.85 (95% CI 1.05 to 2.89)
p-value: p=0.002 for trend
Elevated triglyceride levels are an independent risk factor for first ischaemic stroke in elderly hypertensive patients.
May support triglyceride monitoring for stroke risk stratification in elderly hypertensives; hypothesis-generating for interventional trials.
BACKGROUND: Although hyperlipidaemia was a well-known risk factor for ischaemic stroke, the association between triglyceride and first ischaemic stroke remains uncertain. OBJECTIVES: The present study attempted to explore the relationship between triglyceride and first ischaemic stroke in a Chinese community elderly patients with hypertension. METHODS AND RESULTS: This was a retrospective cohort study. We enrolled 3249 consecutive elderly patients with hypertension from a community in China between January 2010 and December 2011. Patients were divided into four groups based on the quartiles of triglyceride. Multivariate Cox regression analysis, subgroup and interaction test were performed to evaluate the relationship between triglyceride and first ischaemic stroke. There were a total of 3249 participants including 1455 male and 1794 female, with a mean age of 71.36±7.18 years. At an average follow-up of 5.5 years, 205 patients were identified to have first ischaemic stroke. After adjustment for potential confounders, using the lowest quartiles of triglyceride as the reference, multivariable HR (95% CI) for first ischaemic stroke increased in parallel with the quartiles of triglyceride (HRs were 1.56 (95% CI 1.07 to 2.51), 1.74 (95% CI 1.07 to 2.84) and 1.85 (95% CI 1.05 to 2.89)) from the second to the fourth quartiles, respectively (p=0.002 for trend). Subgroup and interaction analysis showed that there was no interactive effect on triglyceride and first ischaemic stroke. CONCLUSION: Triglyceride was an independent risk factor for first ischaemic stroke among Chinese elderly patients with hypertension.
No takes yet. Share an insight, caveat, or question.
Huang et al. (2019) conducted a cohort in hypertension (n=3,249). Triglyceride levels vs. Lowest quartile of triglyceride was evaluated on first ischaemic stroke (HR 1.85, 95% CI 1.05 to 2.89, p=0.002 for trend). Higher triglyceride levels increased the risk of first ischaemic stroke in elderly hypertensive patients, with the highest quartile showing an HR of 1.85 (95% CI 1.05 to 2.89; p=0.002 for trend).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: