What question did this study set out to answer?

To examine whether high potassium diets reduce macrophage adherence and infiltration into the vascular wall in stroke-prone spontaneously hypertensive rats.

September 24, 2008Journal of Vascular Research

High Potassium Diets Reduce Macrophage Adherence to the Vascular Wall in Stroke-Prone Spontaneously Hypertensive Rats

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Authors

TIToshihiko IshimitsuGeneral / Preventive / Lipids LTLouis TobianGeneral / Preventive / Lipids KSKoh‐ichi SugimotoTokyo Institute of Technology

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Implication

Animal study demonstrates high potassium diets reduce vascular macrophage adherence in hypertensive rats, suggesting endothelial protection reduces stroke risk independently of blood pressure.

Key Points

To examine whether high potassium diets reduce macrophage adherence and infiltration into the vascular wall in stroke-prone spontaneously hypertensive rats.
Stroke-prone spontaneously hypertensive rats (SHRsp) were fed 6% NaCl diets containing normal (0.5%) or high (2.1%) potassium and injected intravenously with 51Cr-labelled peritoneal macrophages before perfusion.
Excised aortas from normal- and high-potassium fed SHRsp were mounted in perfusion chambers and perfused in vitro with labeled macrophages under normotensive and hypertensive pressures.
In vivo macrophage radioactivity was 40% lower in the aorta (p < 0.002) and 52% lower in the brain (p < 0.007) in high-potassium SHRsp versus normal-potassium SHRsp, persisting in blood pressure-matched comparisons (-33% aorta, p < 0.02; -55% brain, p < 0.02).
In vitro aortic macrophage retention under hypertensive perfusion pressure increased by 158% compared to normotensive pressure in normal-potassium SHRsp (p < 0.002), but did not significantly differ between perfusion pressures in high-potassium SHRsp.

Cite This Study

Ishimitsu et al. (2008) studied this question.

synapsesocial.com/papers/6a1925fec27e07dcc0d94de6 https://doi.org/10.1159/000159116

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Implication

Animal study demonstrates high potassium diets reduce vascular macrophage adherence in hypertensive rats, suggesting endothelial protection reduces stroke risk independently of blood pressure.

High Potassium Diets Reduce Macrophage Adherence to the Vascular Wall in Stroke-Prone Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

High Potassium Diets Reduce Macrophage Adherence to the Vascular Wall in Stroke-Prone Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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