Relation of plasma renin to end organ damage and to protection of K+ feeding in stroke-prone hypertensive rats.
Why the study?
Does a high potassium diet protect against end organ damage and renin elevation in stroke-prone hypertensive rats on a high sodium diet?
Population
Male stroke-prone spontaneously hypertensive rats (SHRSP)
Comparison
High sodium diet or high sodium and high… vs Regular diet (0.35% NaCl/1.1% potassium)
Design
Preclinical
Follow-up
12 weeks
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in hypertensive rat models; leaves open translation to human dietary potassium recommendations.
Structured PICO
Does a high potassium diet protect against end organ damage and renin elevation in stroke-prone hypertensive rats on a high sodium diet?
P
Population
Male stroke-prone spontaneously hypertensive rats (SHRSP)
I
Intervention
High sodium diet (4% NaCl/0.75% potassium) or high sodium and high potassium diet (4% NaCl/2.11% potassium)
C
Comparator
Regular diet (0.35% NaCl/1.1% potassium)
O
Outcome
Blood pressure, plasma renin activity, renal and cerebrovascular lesions, and incidence of stroke and mortalitysurrogate
In stroke-prone hypertensive rats, potassium supplementation attenuates the increase in plasma renin activity and renal vascular damage induced by a high sodium diet.
Cite This Study
Volpe et al. (1990) studied this question.