Key result
Microvascular dysfunction acts as a potential pathophysiological link connecting obesity to the development of insulin resistance and hypertension.
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Design
Review
Supports microvascular research targets in obesity-related disease; leaves open whether this mechanism warrants targeted interventions.
Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension.
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Jonk et al. (2007) studied this question. Microvascular dysfunction acts as a potential pathophysiological link connecting obesity to the development of insulin resistance and hypertension.
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