Association of Parental Heart Failure with Risk of Heart Failure in Offspring
Key result
Parental heart failure was associated with an increased 10-year incidence of heart failure in offspring compared to no parental heart failure (2.72% vs 1.62%; HR 1.70; 95% CI 1.11-2.60).
Why the study?
Does having a parent with heart failure increase the risk of heart failure and left ventricular systolic dysfunction in offspring?
Population
2,214 participants of the Framingham Offspring Study in the longitudinal cohort and 1,497 participants in…
Comparison
Having at least one parent with heart failure vs Having parents without heart failure
Design
Cohort
Follow-up
mean 20 years
Authors
Discussion
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Member takes
Implication
May support incorporating parental HF history into offspring risk assessment; leaves open prospective validation before practice change.
Study Design
Type
Cohort (n=2,214)
Structured PICO
Does having a parent with heart failure increase the risk of heart failure and left ventricular systolic dysfunction in offspring?
P
Population
2,214 participants of the Framingham Offspring Study in the longitudinal cohort (mean age 44 years, 1150 women) and 1,497 participants in the cross-sectional cohort (mean age 57 years, 819 women) who underwent routine echocardiography.
I
Intervention
Having at least one parent with heart failure
C
Comparator
Having parents without heart failure
O
Outcome
Prevalence of left ventricular systolic dysfunction (cross-sectional) and risk of developing heart failure (longitudinal)hard clinical
Main Result
Effect estimate: HR 1.70 (95% CI 1.11-2.60)
Absolute Event Rate: 2.72% vs 1.62%
Parental heart failure is an independent risk factor for the development of heart failure and left ventricular systolic dysfunction in offspring, highlighting the importance of familial factors in heart failure risk assessment.
Cite This Study
Lee et al. (2006) conducted a cohort in Heart failure (n=2,214). Parental heart failure vs. No parental heart failure was evaluated on Incidence of heart failure (HR 1.70, 95% CI 1.11-2.60). Parental heart failure was associated with an increased 10-year incidence of heart failure in offspring compared to no parental heart failure (2.72% vs 1.62%; HR 1.70; 95% CI 1.11-2.60).