Key result
Successful percutaneous transvenous mitral commissurotomy significantly improved pulmonary function in patients with severe mitral stenosis, increasing mean FEV1 from 60.18% to 78.32% (p<0.001).
Why the study?
Does Percutaneous Transvenous Mitral Commissurotomy (PTMC) improve pulmonary function and echocardiographic parameters in patients with severe mitral stenosis?
Observational (n=58)
Does Percutaneous Transvenous Mitral Commissurotomy (PTMC) improve pulmonary function and echocardiographic parameters in patients with severe mitral stenosis?
Absolute Event Rate: 78.32% vs 60.18%
p-value: p=<0.001
Successful PTMC in patients with severe mitral stenosis significantly improves both hemodynamic parameters and pulmonary function.
A total of 58 patients of severe mitral stenosis with Wilkins score < 10 were studied, all of them underwent PTMC. Spirometry and peak expiratory flow rate were done before and after PTMC. A follow up echocardiographic assessment of successful PTMC and pulmonary artery systolic pressure were taken. Two patients died of PTMC related procedural complications. There was no dropout. Hemodynamic measurements obtained by echocardiography showed improvement of mean mitral valve area from 0.764 ± 0.1257 cm2 to 1.404 ± 0.1194 cm2 after PTMC (p < 0.001). Transmitral peak pressure gradient decreased from 26.43 + 5.62 mmHg to 11.36 + 2.40 mmHg after PTMC (p < 0.001). Pulmonary artery systolic pressure was decreased from 57.73 ± 17.03 mmHg to 31.27± 8.30 mmHg after the procedure (p < 0.001). pulmonary functions - The mean FEV1 was increased from 60.18 ± 13.054 to 78.32 ± 11.874 after PTMC (p<0.001). The mean FVC was 53.80+ 12.313 before PTMC, which significantly improved to 68.57 + 11.662. PEF also showed an improvement from 223.75 + 62.3215 to 372.05 + 62.2. (p<0.001).
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Khan et al. (2017) conducted an observational in Severe mitral stenosis (n=58). Percutaneous Transvenous Mitral Commissurotomy (PTMC) vs. Baseline (Before PTMC) was evaluated on Mean FEV1 (% predicted) (p=<0.001). Successful percutaneous transvenous mitral commissurotomy significantly improved pulmonary function in patients with severe mitral stenosis, increasing mean FEV1 from 60.18% to 78.32% (p<0.001).
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