Demonstrates Garcinia cambogia's protective effect against ethanol-induced damage in rats, suggesting potential therapeutic use.
Objective: To determine the modulating effect of Garcinia cambogia fruit extract on ethanol induced peroxidative damage in rats. Method: Male albino rats weighing 125 to 150g were administered ethanol (7.11g per kg body weight / day) for 45 days. Ethanol administered rats were treated concomitantly with Garcinia cambogia fruit extract (1g/kg body weight / day) orally for 45 days. After the experimental period the antioxidant enzymes, LPO, conjugated diene in the liver tissue, serum AST, ALT and alkaline phosphatase and lipid levels in both serum and liver tissue were estimated. Results: Co-treatment of the rats with Garcinia cambogia significantly inhibited the rise in lipid levels and also the peroxidative damage caused by ethanol, which is evident from the improved antioxidant status. The levels of serum AST, ALT and alkaline phosphatase were maintained at near normalcy in Garcinia cambogia treated rats. Conclusion: The imbalance in lipid metabolism could be the reason for increase in lipid peroxidation. In our present study the treatment with Garcinia cambogia fruit extract resulted in reduction of both serum and liver lipid to near normalcy. This hypolipidemic property of Garcinia cambogia in turn reduces the peroxidative damage, enhanced by ethanol.
No takes yet. Share an insight, caveat, or question.
MAHENDRAN et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: