Large-Scale Network Distribution of Resting-State Functional Abnormalities in Chronic Kidney Disease and Their Relation to Cognitive Impairment

Yun Fei Wang; H B Chen; Yu Ting Yang; Xiang Kong; L J Zhang

doi:10.1016/j.brainresbull.2026.111969

May 1, 2026Brain Research BulletinOpen Access

Large-Scale Network Distribution of Resting-State Functional Abnormalities in Chronic Kidney Disease and Their Relation to Cognitive Impairment

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Key Points

This research aims to identify functional abnormalities in chronic kidney disease (CKD) and their relationship with cognitive impairment.
Analyzed resting-state functional images to assess abnormalities in large-scale brain networks.
Focused on the default mode network (DMN) and frontal-parietal network (FPN).
Correlated haematocrit levels with cognitive performance using IPL ALFF measurements.
CKD demonstrated extensive functional abnormalities predominantly in the DMN.
Lower haematocrit was significantly linked to poorer cognition (exact metrics not provided).
Functional alterations in FPN were also noted, indicating their role in cognitive deficits.

Implication

Shows resting-state functional abnormalities in chronic kidney disease, suggesting links to cognitive impairment.

Abstract

• CKD showed widespread resting-state functional abnormalities. • Abnormal voxels were concentrated in the DMN and FPN. • DMN was most affected, with FPN also prominently involved. • Lower haematocrit was linked to worse cognition via reduced IPL ALFF.

Discussion

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a192d65fab5b468c44164aa https://doi.org/10.1016/j.brainresbull.2026.111969

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Large-Scale Network Distribution of Resting-State Functional Abnormalities in Chronic Kidney Disease and Their Relation to Cognitive Impairment

Key Points

Implication

Abstract

Discussion

Cite This Study

Large-Scale Network Distribution of Resting-State Functional Abnormalities in Chronic Kidney Disease and Their Relation to Cognitive Impairment

Key Points

Implication

Abstract

Discussion

Cite This Study

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