What does this research mean for the field?

A modified geriatric assessment identifies a high prevalence of health-related deficits in adults with lymphoma across all age groups, including those under 65, despite preserved performance status. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

This study aims to assess the prevalence of health vulnerabilities in adults with lymphoma through a modified geriatric assessment.

May 29, 2026Journal of Clinical Oncology0 citations

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Utility of a modified geriatric assessment to identify impairments in adults of all ages with lymphoma: A prospective observational cohort study.

CJChristopher E. JensenUniversity of North Carolina at Chapel Hill HMHrishika MuthukrishnanUniversity of North Carolina at Chapel Hill KNKirsten A. NyropUniversity of North Carolina at Chapel Hill

Key Points

This study aims to assess the prevalence of health vulnerabilities in adults with lymphoma through a modified geriatric assessment.
Adults with lymphoma (N=97) completed a modified Cancer and Aging Research Group GA at treatment initiation.
The GA evaluated eight domains, including mobility, cognition, and medication burden.
Deficits were compared between adults <65 and ≥65 years.
94% of participants had a KPS ≥80, yet 56% displayed multiple GA-identified deficits.
Common deficits included unintentional weight loss (43%), with significant age-related differences in weight loss (p=0.035) and polypharmacy (p=0.002).
Older adults (≥65) showed higher prevalence of severe polypharmacy (≥10 medications) and high comorbidity (≥4 conditions) compared to younger adults.

Abstract

7091 Background: Performance status assessments may overlook important health vulnerabilities in adults with cancer. While geriatric assessment (GA) systematically evaluates multiple domains including physical function, cognition, psychological health, comorbidity, and nutrition, it has been predominantly studied in older adults. We evaluated the prevalence and patterns of GA-identified deficits among adults of all ages initiating systemic therapy for lymphoma. Methods: Adults with lymphoma enrolled in a prospective registry at an academic cancer center from 2018-2025 completed a modified Cancer and Aging Research Group (CARG) GA at treatment initiation. The assessment included validated measures across eight domains: mobility (Timed Up and Go), falls history, instrumental activities of daily living (IADLs), medication burden, comorbidities, weight loss, cognition (Blessed Orientation-Memory-Concentration test), and psychological health (Mental Health Index-13). Karnofsky Performance Status (KPS) was documented. Prevalence of deficits was compared between adults 14 seconds 5 (2-12) 4 (1-14) 6 (2-19) 1.0 *Reflects missing values (1 each for weight loss, MHI13, daily medications, and comorbid conditions, 10 for BOMC, and 16 for TUG). **P-values from Fisher's exact test.

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Cite This Study

Jensen et al. (Thu,) studied this question.

synapsesocial.com/papers/6a192d7efab5b468c4416571 https://doi.org/https://doi.org/10.1200/jco.2026.44.16_suppl.7091

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