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This research evaluates the impact of geriatric impairments on treatment toxicity in older patients with multiple myeloma.

December 8, 2025BloodOpen Access

Self-reported geriatric impairments and treatment toxicity in older patients with multiple myeloma - a single center prospective study

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Authors

RMRosalyn MararWinnMed CYClaire YeeWinnMed ABAnna BodilyWinnMed

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Implication

Prospective study shows geriatric impairments associate with treatment toxicity in older multiple myeloma patients, suggesting need for personalized approaches.

Key Points

This research evaluates the impact of geriatric impairments on treatment toxicity in older patients with multiple myeloma.
Included patients aged ≥60 years initiating new treatment at Mayo Clinic from March 2023 to June 2024.
Patients completed the CARG GCA electronically before and after 4 treatment cycles.
Collected toxicity data using CTCAE and PRO-CTCAE, and quality of life using PROMIS10-GH SF.
Out of 90 enrolled patients, 59% were newly diagnosed with multiple myeloma.
Over half of participants experienced treatment-related delays or dose reductions despite low physician-reported toxicity.
Significant associations were found between geriatric impairments and grade ≥3 non-hematologic toxicity, such as age and polypharmacy.

Cite This Study

Marar et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4cf https://doi.org/10.1182/blood-2025-715

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Implication

Prospective study shows geriatric impairments associate with treatment toxicity in older multiple myeloma patients, suggesting need for personalized approaches.

Self-reported geriatric impairments and treatment toxicity in older patients with multiple myeloma - a single center prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

Self-reported geriatric impairments and treatment toxicity in older patients with multiple myeloma - a single center prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

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