What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

To evaluate the impact of a dynamic comprehensive geriatric assessment on fitness and outcomes in older adults with acute myeloid leukemia.

December 8, 2025BloodOpen Access

A dynamic comprehensive geriatric assessment demonstrates improvement in patient fitness after induction and predicts survival and treatment tolerability among older adults with newly diagnosed acute myeloid leukemia

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Authors

ETElizabeth TermanUniversity of Chicago JCJohn CursioChicago Department of Public Health MBMirza Faisal BegSimon Fraser University

Discussion

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Implication

Observational trial shows dynamic geriatric assessment improves fitness in older adults with AML, indicating survival and treatment tolerability benefits.

Key Points

To evaluate the impact of a dynamic comprehensive geriatric assessment on fitness and outcomes in older adults with acute myeloid leukemia.
Conducted a prospective observational trial among older adults with newly diagnosed acute myeloid leukemia.
Administered a comprehensive geriatric assessment before and after induction therapy.
Primary outcome measures included early death rate and treatment tolerability based on the ability to complete two cycles of therapy.
28% early death rate was observed in the cohort.
Sarcopenia and Timed Up and Go test identified significant predictors of treatment tolerability.
Post-induction therapy showed improvements in ECOG performance status and cognitive function.

Cite This Study

Terman et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d88b https://doi.org/10.1182/blood-2025-5153

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Implication

Observational trial shows dynamic geriatric assessment improves fitness in older adults with AML, indicating survival and treatment tolerability benefits.

A dynamic comprehensive geriatric assessment demonstrates improvement in patient fitness after induction and predicts survival and treatment tolerability among older adults with newly diagnosed acute myeloid leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

A dynamic comprehensive geriatric assessment demonstrates improvement in patient fitness after induction and predicts survival and treatment tolerability among older adults with newly diagnosed acute myeloid leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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