What question did this study set out to answer?

To evaluate the association of psychosocial vulnerabilities with survival outcomes in older adults undergoing treatment for acute myeloid leukemia.

December 8, 2025Blood

Prospective study of patient-reported depression, and cognitive and functional impairment, and impact on survival and induction mortality in fit adults age ≥60 years receiving intensive chemotherapy (IC) for Acute Myeloid Leukemia (AML): Prospective geriatric assessment (GA) report from ECOG-ACRIN (EA) E2906 randomized study

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Authors

JFJames M. ForanJacksonville College LCLi ChenInstitute of Soil Science ZSZhuoxin SunHebei Medical University

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Implication

Prospective study demonstrates associations of psychosocial factors with survival in older adults receiving intensive chemotherapy for AML, suggesting needs for tailored interventions.

Key Points

To evaluate the association of psychosocial vulnerabilities with survival outcomes in older adults undergoing treatment for acute myeloid leukemia.
Conducted a prospective study on fit older adults (≥60 years) with AML receiving intensive chemotherapy.
Assessments included patient-reported outcomes for depression, cognitive function, and activities of daily living.
Statistical analyses used included Cox proportional hazards models to evaluate associations with overall survival and induction mortality.
31% reported depressive symptoms, with significant associations found between higher depression levels and inferior survival outcomes.
Cognitive impairment was present in 37% according to Mini-Mental Exam scores, impacting survival.
Functional impairment and higher comorbidity rates were prevalent, contributing to increased induction mortality.

Cite This Study

Foran et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d979 https://doi.org/10.1182/blood-2025-882

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Implication

Prospective study demonstrates associations of psychosocial factors with survival in older adults receiving intensive chemotherapy for AML, suggesting needs for tailored interventions.

Discussion

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Implication

Key Points

Cite This Study

Discussion

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Implication

Key Points

Cite This Study

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