What question did this study set out to answer?

To evaluate the prognostic impact of the GAH scale in older patients with hematological malignancies.

December 8, 2025BloodOpen Access

Geriatric assessment in hematology (GAH) scale for survival prognostication and early treatment discontinuation in older adults: Final results from the spanish hematogeriatric registry

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Authors

RCRaúl CórdobaHospital Universitario Fundación Jiménez Díaz JBJoan BargayHospital Son Llatzer CBConcepción BoquéInstitut Català d'Oncologia

Discussion

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Implication

Multicenter observational study found GAH scale improves survival prediction in older patients with hematological malignancies, highlighting frailty assessment.

Key Points

To evaluate the prognostic impact of the GAH scale in older patients with hematological malignancies.
Multicenter, prospective, observational study
Included 285 patients aged ≥70 years with hematological malignancies
Collected GAH, ECOG performance status, and CIRS scores
Conducted survival analyses using Kaplan-Meier and log-rank test
Overall mortality in the cohort was 64.8% after a median follow-up of 58 months
GAH score was a strong predictor of overall survival
Identification of distinct prognostic groups based on GAH cut-off scores of 22 and 81
GAH identified hidden frailty in patients considered low-risk by ECOG performance status

Cite This Study

Córdoba et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e04a https://doi.org/10.1182/blood-2025-6266

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Implication

Multicenter observational study found GAH scale improves survival prediction in older patients with hematological malignancies, highlighting frailty assessment.

Geriatric assessment in hematology (GAH) scale for survival prognostication and early treatment discontinuation in older adults: Final results from the spanish hematogeriatric registry

Discussion

Member takes

Implication

Key Points

Cite This Study

Geriatric assessment in hematology (GAH) scale for survival prognostication and early treatment discontinuation in older adults: Final results from the spanish hematogeriatric registry

Discussion

Member takes

Implication

Key Points

Cite This Study

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