What question did this study set out to answer?

The study aims to evaluate the effectiveness of geriatric assessments and frailty indices in predicting outcomes in older adults with acute myeloid leukemia.

December 8, 2025BloodOpen Access

Age-ing study: A prospective evaluation of geriatric, patient-reported and frailty assessments to predict outcomes in older adults with acute myeloid leukemia

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Authors

NSNisha SinghRoyal North Shore Hospital ALAndrew LivingstonUnited States Department of Veterans Affairs APAlexander E. PerlUniversity of Pennsylvania

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Implication

Prospective evaluation shows adverse outcomes in older AML patients, highlighting frailty assessment importance.

Key Points

The study aims to evaluate the effectiveness of geriatric assessments and frailty indices in predicting outcomes in older adults with acute myeloid leukemia.
Prospective observational study at a single center involving patients aged ≥50 newly diagnosed with AML
Patients received either intensive or non-intensive therapies
Geriatric assessments included physical function, PROs, and frailty index
Survival outcomes evaluated using Cox proportional hazards and Kaplan–Meier models
Median age of participants was 66 years; 39.6% were aged ≥70
Higher frailty levels linked to worse overall survival outcomes
At 1 month, physical function and PRO scores worsened significantly
Patients ≥75 years had poorer overall survival compared to younger patients

Cite This Study

Singh et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf88 https://doi.org/10.1182/blood-2025-2843

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Age-ing study: A prospective evaluation of geriatric, patient-reported and frailty assessments to predict outcomes in older adults with acute myeloid leukemia

Discussion

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Implication

Key Points

Cite This Study

Age-ing study: A prospective evaluation of geriatric, patient-reported and frailty assessments to predict outcomes in older adults with acute myeloid leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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