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July 29, 2026Blood AdvancesOpen Access

Self-Reported Geriatric Impairments and Treatment Toxicity in Older Patients with Multiple Myeloma-A Single Center Prospective Study

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Authors

NANadine AbdallahMayo Clinic RMRosalyn MararMayo Clinic CYClaire YeeWinnMed

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Implication

Prospective study evaluates how self-reported geriatric impairments impact treatment toxicity in older adults with multiple myeloma, suggesting a need for improved monitoring.

Key Points

This study examines the relationship between self-reported geriatric impairments and treatment toxicity in older patients with multiple myeloma.
Single-center prospective study targeting patients ≥60 years with multiple myeloma.
Participants completed electronic comprehensive geriatric assessment and patient-reported outcome questionnaires at baseline and after 4 months.
Outcomes included treatment toxicity, healthcare utilization, and health-related quality of life.
Among 90 patients, geriatric impairments, particularly in physical function, were prevalent.
Older age and comorbidities increased high-grade non-hematological toxicity rates, as reported by patients, compared to physicians.
Frailty was found in 22% of participants, linking it to worse baseline health-related quality of life and increased toxicity, yet no impact on treatment adaptations.

Cite This Study

Abdallah et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2aec8da07d9defa669a https://doi.org/10.1182/bloodadvances.2026020579

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Implication

Prospective study evaluates how self-reported geriatric impairments impact treatment toxicity in older adults with multiple myeloma, suggesting a need for improved monitoring.

Self-Reported Geriatric Impairments and Treatment Toxicity in Older Patients with Multiple Myeloma-A Single Center Prospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Self-Reported Geriatric Impairments and Treatment Toxicity in Older Patients with Multiple Myeloma-A Single Center Prospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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