Shows interference of adulterants in drug assays, suggesting limitations of TLC methods.
Urine screening for determining illicit drug use has become a necessary adjunct to treat drug addicts. Some of the laboratories use thin layer chromatography (TLC) for screening drugs of abuse in urine. Six adulterants viz. sodium chloride, sodium bicarbonate, liquid detergent soap (Labolene), bleacing powder, vinegar, ascorbic acid, gave false negative results for morphine, diazepam and phenobarbital drug assays when screened by TLC. Of the three drugs tested, morphine was found to be most sensitive to all adulterants. Adulterants interfered at lower concentration for morphine assay when analysed by TLC methodology than the reported EMIT technique.
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Raka Jain (1993) studied this question.
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