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May 29, 2026Journal of Clinical Oncology

First-in-human study of cavitation-enhanced drug delivery (CEeDD) by sonosensitive particles and focused ultrasound applied to colorectal metastases in the liver.

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Authors

JRJeffrey RubasinghamCCCalum Crakee-Therapeutics (United Kingdom)CCChristian Coviello

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Implication

Randomized trial evaluates enhanced drug delivery and efficacy of ultrasound-assisted therapy in colorectal liver metastases, indicating promising outcomes.

Key Points

  • This study aims to assess a novel approach to enhance drug delivery in colorectal liver metastases via cavitation.
  • Evaluated safety and drug delivery in three patient cohorts.
  • Cohort 1 focused on safety with ultrasound-activated sonosensitive particles.
  • Cohorts 2 and 3 assessed drug concentrations and early efficacy with or without cavitation.
  • No grade 3 or higher adverse events reported in Cohort 1.
  • Cohort 2 showed increased cetuximab concentrations in tumors treated with cavitation (7.1 vs 3.7 ng/mL).
  • Cohort 3 revealed an objective response rate of 85.7% with cavitation compared to 66.7% without.

Cite This Study

Rubasingham et al. (2026) studied this question.

synapsesocial.com/papers/6a192f07fab5b468c44185achttps://doi.org/10.1200/jco.2026.44.16_suppl.3549
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real time cavitation monitoring during ultrasound-mediated drug delivery in normothermically perfused human tumour-bearing livers2024
  2. 2CEUS with VEGFR2-targeted microbubbles for monitoring of early immunotherapy effects in a colorectal cancer model2026
  3. 3Abstract No. 151 ▪ FEATURED ABSTRACT Update on the Use of Ultrasound Microbubble Destruction for Improving Radioembolization Therapy of Hepatocellular Carcinoma2024
  4. 4Recent advances in acoustic cavitation-inducible materials for cancer sonotheranostics2026 · 2 citations
  5. 5Early prediction of response to chemotherapy with Cetuximab in colorectal liver metastasis with contrast-enhanced ultrasound perfusion analysis2026