What question did this study set out to answer?

To assess the utility of CEUS with VEGFR2-targeted microbubbles in monitoring early treatment effects from immunotherapy in colorectal cancer.

August 2, 2026Cancer ImagingOpen Access

CEUS with VEGFR2-targeted microbubbles for monitoring of early immunotherapy effects in a colorectal cancer model

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Randomized trial evaluates early treatment effects of dual immunotherapy in a mouse model, indicating a promising imaging approach.

To assess the utility of CEUS with VEGFR2-targeted microbubbles in monitoring early treatment effects from immunotherapy in colorectal cancer.
Established murine colorectal cancer allografts in 29 female Balb/c mice (therapy n=15; control n=14).
Conducted baseline and follow-up CEUS measurements at multiple timepoints before and after treatment.
Performed immunohistochemistry to analyze tumor characteristics and immune response.
Follow-up WiAUC was significantly lower in the therapy group compared to controls at FU1 (4,029 vs. 6,391, p < 0.001) and FU2 (1,028 vs. 2,049, p < 0.001).
VEGFR2-targeted microbubble binding dropped significantly in treated mice compared to controls (p < 0.001 for SI 8min and SI 10min).
Immunohistochemistry revealed increased CD8 infiltration and apoptosis, along with decreased microvascular density and VEGFR2 expression in treated tumors (all p < 0.05).

Herr et al. (2026) studied this question.

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