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May 29, 2026Indian Journal of OphthalmologyOpen Access

Analysis of the therapeutic effects of anti-vascular endothelial growth factor treatment based on indocyanine green angiographic staining patterns in patients with central serous chorioretinopathy

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Authors

BHBo-Een HwangSeoul St. Mary's HospitalMKMirinae KimSeoul St. Mary's HospitalYPYoung‐Geun ParkSt. Mary's Hospital

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Implication

Retrospective study evaluates anti-VEGF treatment response using ICGA texture analysis in CSC, suggesting key biomarkers.

Key Points

  • This research aims to identify predictive factors for anti-VEGF treatment response in central serous chorioretinopathy using ICGA texture analysis.
  • Retrospective analysis of 135 CSC patients
  • ICGA images assessed at four timepoints after dye injection: 30s, 3min, 10min, and 15min
  • GLCM texture analysis quantified contrast, inverse difference moment (IDM), and entropy in a 6-mm macular region.
  • 68 eyes were classified as good responders and 67 as poor responders.
  • Poor responders had significantly higher contrast and entropy, and lower IDM in the 10- and 15-minute phases (all P < 0.005).
  • Entropy in the mid-late phase (15 min) showed the highest predictive value (AUC = 0.72) correlating with CCFD + SVFS at P = 0.04.

Cite This Study

Hwang et al. (2026) studied this question.

synapsesocial.com/papers/6a192f1bfab5b468c441872dhttps://doi.org/10.4103/ijo.ijo_2592_25
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