What does this research mean for the field?

Adverse social determinants of health are associated with significantly increased mortality, poorer survival, and a higher risk of severe sepsis in patients with prostate cancer. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to understand how social determinants of health impact long-term outcomes in prostate cancer patients.

May 29, 2026Journal of Clinical Oncology

Social determinants of health and long-term outcomes in prostate cancer: Mortality, survival, and comorbidity risks in a propensity score–matched federated database analysis.

Q: What are the key findings of this study?

Adverse social determinants of health in prostate cancer increased mortality risk compared to no adverse SDOH (22.0% vs 17.3%; RR 1.272; 95% CI 1.209-1.338; p<0.001).

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Prostate cancer (n=25252). Intervention: Adverse social determinants of health (SDOH) vs. No adverse SDOH codes. Primary outcome: Mortality (RR 1.272, 95% CI 1.209-1.338, p=< 0.001).

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Key result

Adverse SDOH linked to ~27% higher mortality risk in prostate cancer.

RR 1.272
95% CI 1.209-1.338
P<0.001
n=25,252

Why the study?

Social determinants of health influence health outcomes, but their long-term effects on prostate cancer patients remain underexplored.

Does the presence of adverse social determinants of health worsen mortality and survival in patients with prostate cancer?

Key Points

This research aims to understand how social determinants of health impact long-term outcomes in prostate cancer patients.
Retrospective cohort study using TriNetX federated database involving 14,595 PCa patients with adverse SDOH and 875,545 without.
Propensity score matching (1:1) was employed to balance demographics between cohorts.
Outcomes like mortality, sepsis, and sexual dysfunction were analyzed using risk ratios and Kaplan-Meier survival methods.
Cohorts had higher mortality risk with adverse SDOH (22.0% vs 17.3%; RR 1.272, 95% CI 1.209-1.338; p < 0.001).
Adverse SDOH associated with worse survival (median 2821 vs 5246 days; HR 2.018, 95% CI 1.906-2.137; p < 0.001).
Severe sepsis risk was elevated (5.6% vs 4.7%; RR 1.199, 95% CI 1.074-1.339; p < 0.001).

Study Design

Type

Cohort (n=25,252)

Multicenter

Yes

Structured PICO

Does the presence of adverse social determinants of health worsen mortality and survival in patients with prostate cancer?

Population

25,252 propensity score-matched adults (≥18 years) with prostate cancer (12,626 with adverse SDOH, 12,626 without SDOH), mean age ~72 years, ~56% White, ~25% Black.

Intervention

Presence of adverse social determinants of health (SDOH) such as housing instability, food insecurity, and low income

Comparator

Absence of adverse SDOH codes

Outcome

Mortality, survival, sepsis, sexual dysfunction, and comorbidities across major organ systemshard clinical

Main Result

Effect estimate: RR 1.272 (95% CI 1.209-1.338)

Absolute Event Rate: 22% vs 17.3%

p-value: p=< 0.001

Adverse social determinants of health are significantly associated with increased mortality, poorer survival, and heightened sepsis risk in patients with prostate cancer.

Discussion

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Implication

Adverse SDOH linked to worse prostate cancer survival; hypothesis-generating for interventions and should not yet change practice.

Cite This Study

Singh et al. (2026) conducted a cohort in Prostate cancer (n=25,252). Adverse social determinants of health (SDOH) vs. No adverse SDOH codes was evaluated on Mortality (RR 1.272, 95% CI 1.209-1.338, p=< 0.001). Adverse social determinants of health in prostate cancer increased mortality risk compared to no adverse SDOH (22.0% vs 17.3%; RR 1.272; 95% CI 1.209-1.338; p<0.001).

synapsesocial.com/papers/6a192f1bfab5b468c44187cc https://doi.org/10.1200/jco.2026.44.16_suppl.12119

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Social determinants of health and long-term outcomes in prostate cancer: Mortality, survival, and comorbidity risks in a propensity score–matched federated database analysis.

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Social determinants of health and long-term outcomes in prostate cancer: Mortality, survival, and comorbidity risks in a propensity score–matched federated database analysis.

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider