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This research investigates the role of MMP-9 genotypes in the susceptibility to oral cancer among smokers.

MMP-9 Genotypes Serve as Oral Cancer Predictive Marker for Smokers

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Case-control study investigates MMP-9 genetic variants and oral cancer risk in smokers, suggesting a predictive role.

This research investigates the role of MMP-9 genotypes in the susceptibility to oral cancer among smokers.
Case-control design involving 958 oral cancer patients and 958 controls in Taiwan.
Genotyping for MMP-9 rs3918242 was performed using PCR-RFLP.
Statistical assessment included chi-square tests and odds ratios for association evaluation.
No significant associations were found between MMP-9 genotypes and overall oral cancer risk.
Smokers with the TT genotype showed a significantly increased risk of oral cancer (adjusted OR=1.91, 95% CI=1.04-3.88).
Allelic analysis indicated no significant effect of the T allele on susceptibility (OR=1.17, 95% CI=0.98-1.40, p=0.0843).

SHIH et al. (2026) studied this question.

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