What does this research mean for the field?

While the MMP-2 rs243865 polymorphism does not independently determine hepatocellular carcinoma susceptibility overall, the TT genotype significantly increases HCC risk in Taiwanese males, smokers, and alcohol drinkers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine the association between two functional MMP-2 promoter polymorphisms (rs243865 and rs2285053) and hepatocellular carcinoma risk, including interactions with environmental exposures.

September 2, 2026Anticancer ResearchOpen Access

MMP-2 rs243865 Polymorphism as a Risk Modifier of Hepatocellular Carcinoma in Taiwanese Males, Smokers and Alcohol Consumers

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Authors

TYTE-CHENG YUEH MWMING-HSIEN WUChina Medical University MYMEI-DUE YANGChina Medical University

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Implication

Case-control study reveals MMP-2 rs243865 TT genotype increases liver cancer risk in male smokers and drinkers, highlighting gene-environment interactions in carcinogenesis.

Key Points

To examine the association between two functional MMP-2 promoter polymorphisms (rs243865 and rs2285053) and hepatocellular carcinoma risk, including interactions with environmental exposures.
Conducted a hospital-based case-control study at China Medical University Hospital in Taichung, Taiwan, enrolling 298 hepatocellular carcinoma patients and 889 age- and sex-matched cancer-free controls.
Genotyped MMP-2 promoter polymorphisms rs243865 and rs2285053 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays.
Performed stratified statistical analyses to evaluate gene-environment interactions across sex, smoking status, and alcohol drinking status.
Neither rs243865 (CT+TT vs CC: OR=1.20, 95% CI=0.87-1.66, p=0.2944) nor rs2285053 (CT+TT vs CC: OR=1.12, 95% CI=0.86-1.46, p=0.4219) exhibited an overall independent association with hepatocellular carcinoma risk.
Stratified analyses of rs243865 showed significantly increased cancer risk among TT carriers who were male (OR=3.24, 95% CI=1.12-9.37, p=0.0488), smokers (OR=6.46, 95% CI=1.65-25.29, p=0.0055), or alcohol drinkers (OR=9.69, 95% CI=1.99-47.13, p=0.0022).
The rs2285053 polymorphism demonstrated no statistically significant association with cancer risk across any analyzed genetic model or environmental subgroup.

Cite This Study

YUEH et al. (2026) studied this question.

synapsesocial.com/papers/6a97e318c562ede874ec7b57 https://doi.org/10.21873/anticanres.18339

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Implication

Case-control study reveals MMP-2 rs243865 TT genotype increases liver cancer risk in male smokers and drinkers, highlighting gene-environment interactions in carcinogenesis.

MMP-2 rs243865 Polymorphism as a Risk Modifier of Hepatocellular Carcinoma in Taiwanese Males, Smokers and Alcohol Consumers

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Implication

Key Points

Cite This Study

MMP-2 rs243865 Polymorphism as a Risk Modifier of Hepatocellular Carcinoma in Taiwanese Males, Smokers and Alcohol Consumers

Discussion

Member takes

Implication

Key Points

Cite This Study

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