Key result
Specific MMP-2 gene variants are linked to increased renal cell carcinoma susceptibility in Taiwanese adults.
Why the study?
The relationship between MMP-2 genetic polymorphisms and renal cell carcinoma risk has rarely been investigated, particularly in the Taiwanese population.
Is the MMP-2 rs243865 genotype associated with increased susceptibility to renal cell carcinoma?
Population
118 RCC patients and 590 cancer-free controls in Taiwan
Comparison
MMP-2 rs243865 and rs2285053 genotypes with smoking, alcohol drinking, and hypertension status
Design
Hospital-based case-control study
Authors
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The MMP-2 rs243865 TT genotype is associated with a significantly increased risk of renal cell carcinoma in a Taiwanese population, potentially interacting with smoking, alcohol, and hypertension.
Case-Control (n=708)
Is the MMP-2 rs243865 genotype associated with increased susceptibility to renal cell carcinoma?
Odds Ratio: 4.29 (95% CI 1.56–11.83)
p-value: p=0.0069
The MMP-2 rs243865 TT genotype is associated with a significantly increased risk of renal cell carcinoma in a Taiwanese population, potentially interacting with smoking, alcohol, and hypertension.
Chang et al. (2026) conducted a case-control in Renal cell carcinoma (RCC) (n=708). MMP-2 rs243865 TT genotype vs. MMP-2 rs243865 CC genotype was evaluated on Renal cell carcinoma susceptibility (OR 4.29, 95% CI 1.56-11.83, p=0.0069). The MMP-2 rs243865 TT genotype was associated with a markedly increased risk of renal cell carcinoma compared to the CC genotype (OR 4.29; 95% CI 1.56-11.83; p=0.0069).
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