Key result
A higher resting heart rate was independently associated with increased arterial stiffness in normotensive adults, with cfPWV increasing approximately 0.02 m/s for each 1 bpm increase.
Cross-Sectional (n=102)
A higher resting heart rate is independently associated with increased aortic stiffness in healthy normotensive adults, suggesting a potential mechanism for the prognostic role of heart rate in cardiovascular morbidity.
Answers are grounded in this paper and cite their sources.
May inform risk stratification in normotensives; leaves open causality and needs prospective confirmation.
BACKGROUND AND OBJECTIVES: Large-artery stiffness is an independent predictor of cardiovascular disease (CVD), and carotid-femoral pulse wave velocity (cfPWV) is considered the gold standard measure of arterial stiffness. A resting heart rate is an easily measured vital sign that is also associated with CVD morbidity and mortality. Previous studies have reported the significant relationship of a resting heart rate with arterial stiffness as measured by cfPWV only in hypertensive subjects; their relationship in nonhypertensive subjects remains unknown. The present study, therefore, examined their relationship in normotensive subjects. SUBJECTS AND METHODS: In 102 healthy Korean Americans between ages 20 and 60 years, their resting heart rate was measured by an automated blood pressure measuring device after a 10 minute rest in the supine position. Arterial stiffness was measured by cfPWV using the SphygmoCor device. RESULTS: The mean resting heart rate of participants (mean age, 39.64 years; 59% women) was 61.91 bpm (standard deviation [SD], 9.62 bpm) and mean the cfPWV was 6.99 (SD, 1.14) m/s. A multiple regression analysis showed that a resting heart rate is a significant predictor of cfPWV after controlling for age, body mass index, and mean arterial pressure. For one bpm increase of resting heart rate, cfPWV increased approximately 0.02 m/s. CONCLUSION: Our results suggest that a higher resting heart rate is independently associated with increased arterial stiffness as measured by cfPWV in normotensive adults. Arterial stiffness may explain the prognostic role of an individual's heart rate in cardiovascular morbidity and mortality.
No takes yet. Share an insight, caveat, or question.
Logan et al. (2016) conducted a cross-sectional in Healthy normotensive adults (n=102). Resting heart rate was evaluated on Carotid-femoral pulse wave velocity (cfPWV) (β 0.0196, p=0.0225). A higher resting heart rate was independently associated with increased arterial stiffness in normotensive adults, with cfPWV increasing approximately 0.02 m/s for each 1 bpm increase.
Synapse has enriched 10 related papers. Consider them for comparative context: