A novel method using pressure responses to changes in LVAD flow can quantify left ventricular elastance and resistance in a sheep model, which may help optimize LVAD weaning.
May aid LV parameter assessment during LVAD support in animals; leaves open translation to clinical weaning protocols.
Optimizing the procedure of weaning the left ventricle from a left ventricular assist device requires the determination of the momentaneous condition of the left ventricle. In sheep, a method was developed to momentaneously quantify the left ventricular condition. The left ventricular pump condition was quantified by the time-varying parameters elastance and resistance. They were determined from perturbations in the left ventricular pressure of two subsequent beats induced by changes in flow of the assist device. The end-diastolic volume of the ventricle was estimated without directly measuring ventricular volume. Maximum elastance and resistance were 201.3 +/- 32.7 [Pa/ml] and 12.3 +/- 1.6 [Pa.s/ml], respectively (mean +/- SE). The ventricular time constant, defined by the ratio of resistance of elastance, was 84.6 +/- 17.1 [ms] (mean +/- SE).
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Kunst et al. (1994) studied this question.
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