Key result
Bicuspid aortic valves were associated with larger aortic diameters at all ascending aortic levels compared to matched tricuspid aortic valve controls (P<0.01).
Why the study?
Are bicuspid aortic valves associated with greater aortic dilatation compared to tricuspid aortic valves with matched valvular lesions?
Observational (n=195)
Are bicuspid aortic valves associated with greater aortic dilatation compared to tricuspid aortic valves with matched valvular lesions?
p-value: p=<0.01
Bicuspid aortic valves are associated with intrinsic aortic dilatation beyond what is predicted by hemodynamic factors like regurgitation or stenosis alone.
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Supports intrinsic aortopathy beyond hemodynamics; extends matched case-control data but leaves open prospective validation.
Keane et al. (2000) conducted an observational in Bicuspid aortic valves (n=195). Bicuspid aortic valve vs. Tricuspid aortic valve with matched valvular lesions was evaluated on Aortic diameters at all ascending aortic levels (p=<0.01). Bicuspid aortic valves were associated with larger aortic diameters at all ascending aortic levels compared to matched tricuspid aortic valve controls (P<0.01).
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