Key result
Experimental models suggest that the first beats of torsade de pointes occur due to early afterdepolarizations and triggered activity, while subsequent beats may be driven by reentry.
Experimental models suggest that torsade de pointes is initiated by early afterdepolarizations and triggered activity, with subsequent beats potentially driven by reentry.
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May guide QT-prolonging drug avoidance; leaves open clinical translation of reentry-targeted TdP strategies.
Lars Eckardt (1998) conducted a review in Torsade de pointes. Experimental models (in vitro and in vivo) was evaluated. Experimental models suggest that the first beats of torsade de pointes occur due to early afterdepolarizations and triggered activity, while subsequent beats may be driven by reentry.
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