Key result
Tuberculosis is the leading cause of constrictive pericarditis, contributing to high morbidity and mortality, and requires further research into its etiology, pathophysiology, and treatment.
Why the study?
Tuberculosis is the leading cause of constrictive pericarditis and affects its management across multiple aspects, contributing to high morbidity and mortality.
This review highlights the etiology, pathophysiology, and management of tuberculosis constrictive pericarditis, emphasizing the need for further research and the development of animal models.
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TB drives most constrictive pericarditis cases with high morbidity; leaves open etiology, pathophysiology, and treatment research.
Constrictive pericarditis (CP) characterized by the presence of a thick, fibrotic and/or calcified non-compliant pericardium limits diastolic filling and forces one side of the heart to fill at the expense of the other side. CP results in right heart failure and even reconstruction of the heart, especially for CP caused by tuberculosis (TB). As the leading cause of CP, TB is affecting the management of CP from many aspects, which contributes to high morbidity and mortality. The purpose of this manuscript is to: (1)Review the etiology, epidemiology, pathophysiology, diagnosis, treatment of tuberculosis constrictive pericarditis (TBCP); (2)Review animal models for CP or pericarditis through different methods; (3)Remind us that more research should be done for TBCP.
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Wang et al. (2020) conducted a review in Tuberculosis constrictive pericarditis. Tuberculosis is the leading cause of constrictive pericarditis, contributing to high morbidity and mortality, and requires further research into its etiology, pathophysiology, and treatment.
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