Key result
CTA-derived axial LA area accurately detects LA enlargement in persistent AF with ~0.92 AUC.
Why the study?
This study aimed to identify parameters for rapidly and accurately diagnosing left atrial enlargement in patients with persistent atrial fibrillation using CT cross-sections.
Does axial left atrial area (LAA) measured by CTA accurately diagnose left atrial enlargement in patients with persistent atrial fibrillation?
Cross-Sectional (n=227)
Blinded to patient details
No
Does axial left atrial area (LAA) measured by CTA accurately diagnose left atrial enlargement in patients with persistent atrial fibrillation?
Effect estimate: AUC 0.917 (95% CI 0.873-0.949)
Axial left atrial area (LAA) measured by CTA provides a rapid, accurate, and easily accessible parameter for diagnosing left atrial enlargement in patients with persistent atrial fibrillation.
May support CTA for LAE diagnosis in persistent AF; leaves open need for prospective validation before practice change.
The post-processing technology of CTA offers significant advantages in evaluating left atrial enlargement (LAE) in patients with persistent atrial fibrillation (PAF). This study aims to identify parameters for rapidly and accurately diagnosing LAE in patients with PAF using CT cross-sections. Left atrial pulmonary venous (PV) CT was performed to 300 PAF patients with dual-source CT, and left atrial volume (LAV), left atrial anteroposterior diameter (LAD1), left atrial transverse diameter (LAD2), and left atrial area (LAA) were measured in the ventricular end systolic (ES) and middle diastolic (MD). LA index (LAI) = LA parameter/body surface area (BSA). Left atrial volume index (LAVIES) > 77.7 ml/m2 was used as the reference standard for the LAE diagnosis. 227 patients were enrolled in the group, 101 (44.5%) of whom had LAE. LAVES and LAVMD (r = 0.983), LAVIES and LAVIMD (r = 0.984), LAAES and LAVIES (r = 0.817), LAAMD and LAVIES (r = 0.814) had strong positive correlations. The area under curve (AUC) showed that all measured parameters were suitable for diagnosing LAE, and the diagnostic efficacy was compared as follows: LAA/LAAI> LAD> the relative value index of LAD, LAD2> LAD1. LAA and LAAI demonstrated comparable diagnostic efficacy, with LAA being more readily available than LAAI. The axial LAA measured by CTA can be served as a parameter for the rapid and accurate diagnosis of LAE in patients with PAF.
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Lin et al. (2024) conducted a cross-sectional in Persistent atrial fibrillation (n=227). Computed tomography angiography (CTA) left atrial area (LAA) measurement vs. Left atrial volume index (LAVI) > 77.7 ml/m2 (reference standard) was evaluated on Diagnostic accuracy (AUC) of end-systolic left atrial area (LAAES) for detecting left atrial enlargement (AUC 0.917, 95% CI 0.873-0.949). The axial left atrial area measured by computed tomography angiography accurately diagnosed left atrial enlargement in patients with persistent atrial fibrillation, achieving an AUC of 0.917.
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