Key result
Cardiac MR tagging using a clinical 1.5T system successfully measured myocardial strain with subendocardial resolution in both normal rats and a rat model of acute myocardial infarction.
Why the study?
Is cardiac MR tagging feasible in rats using a standard clinical 1.5T MR system?
Is cardiac MR tagging feasible in rats using a standard clinical 1.5T MR system?
Cardiac MR tagging with subendocardial resolution is feasible in small animal models using widely available clinical 1.5T MR systems, facilitating cardiovascular research.
Feasible in rat MI models on clinical 1.5T scanners; leaves open translation to human studies and practice.
The purpose of this study was to assess the feasibility of cardiac magnetic resonance (MR) tagging in rats on a standard clinical 1.5T MR system. Small animal models have been largely used as an experimental model in cardiovascular disease studies but mainly on high field systems (>4T) dedicated to research. Given the larger availability of routine clinical MR systems in centers with active cardiac research programs, it is of great interest to perform small animal imaging on whole-body MR systems of moderate field strength. The feasibility study was performed on 7 rats within 6 to 8 hours after myocardial infarction and 3 normal control rats. Myocardial strain was measured successfully in normal rats using the harmonic phase (ie, HARP) method, and a transmural gradient was demonstrated. In a rat model of acute occlusion/reperfusion, the myocardial circumferential strains were decreased, but the transmural strain gradient was preserved. This study demonstrated the feasibility of cardiac MR tagging in rats with a subendocardial resolution using a clinical 1.5T system.
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Ivancevic et al. (2007) studied Myocardial infarction (n=10). Cardiac MR tagging using CSPAMM on a 1.5T clinical system vs. Normal control rats was evaluated on Feasibility of cardiac MR tagging and myocardial strain measurement. Cardiac MR tagging using a clinical 1.5T system successfully measured myocardial strain with subendocardial resolution in both normal rats and a rat model of acute myocardial infarction.
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