Key result
Plasma proteome analysis provides insight into the causative drivers of pulmonary vascular disease and can guide drug development and personalized medicine.
Why the study?
Clinical management of pulmonary hypertension has relied on heart-derived proteins like BNP and troponin, leaving the plasma proteome reflecting the pulmonary vasculature relatively untapped.
High-throughput plasma proteomics combined with network analysis and genetic data can advance the molecular classification and personalized treatment of pulmonary hypertension.
May inform targeted therapies in pulmonary hypertension; leaves open clinical translation pending prospective validation.
The plasma proteome is rich in information. It comprises proteins that are secreted or lost from cells as they respond to their local environment. Changes in the constitution of the plasma proteome offer a relatively non-invasive report on the health of tissues. This is particularly true of the lung in pulmonary hypertension, given the large surface area of the pulmonary vasculature in direct communication with blood. So far, this is relatively untapped; we have relied on proteins released from the heart, specifically brain natriuretic peptide and troponin, to inform clinical management. New technology allows the measurement of a larger number of proteins that cover a broad range of molecular pathways in a single small aliquot. The emerging data will yield more than just new biomarkers of pulmonary hypertension for clinical use. Integrated with genomics and with the help of new bioinformatic tools, the plasma proteome can provide insight into the causative drivers of pulmonary vascular disease and guide drug development.
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Martin R. Wilkins (2020) conducted a review in Pulmonary hypertension. Plasma proteome analysis provides insight into the causative drivers of pulmonary vascular disease and can guide drug development and personalized medicine.
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