Why the study?
Despite the established link between obesity and cardiovascular disease, the optimal anthropometric index for risk prediction remains uncertain.
Does the inclusion of obesity indices in the SCORE2 model improve the prediction and reclassification of 20-year ASCVD risk in healthy adults?
Population
3,042 adults free of CVD in Athens metropolitan area, Greece
Comparison
Various anthropometric indices included in the SCORE2 model vs SCORE2 alone
Design
Prospective cohort study
Follow-up
20-year
Key result
The inclusion of any individual obesity index within the SCORE2 model enhanced its discriminatory power and improved risk reclassification for 20-year ASCVD incidence.
Authors
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May refine SCORE2-based ASCVD prediction; leaves open prospective validation before any practice change.
Cohort (n=3,042)
No
Does the inclusion of obesity indices in the SCORE2 model improve the prediction and reclassification of 20-year ASCVD risk in healthy adults?
Obesity indices enhance the predictive accuracy and risk reclassification of the SCORE2 model for 20-year ASCVD risk in the general population.
Giannakopoulou et al. (2025) conducted a cohort in Cardiovascular disease risk (n=3,042). Anthropometric indices (obesity indices) vs. SCORE2 model alone was evaluated on 20-year atherosclerotic cardiovascular disease (ASCVD) incidence. The inclusion of any individual obesity index within the SCORE2 model enhanced its discriminatory power and improved risk reclassification for 20-year ASCVD incidence.