Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2026Clinical Obesity

Total and central adiposity indices and adipose dysfunction moderately predict 20-year incident T2D.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

The study was conducted to evaluate the association between indices of adiposity and the 20-year cumulative incidence of type 2 diabetes among apparently healthy adults.

Do obesity-related anthropometric and dysfunctional adipose tissue-related indices predict the 20-year cumulative incidence of type 2 diabetes in apparently healthy adults?

Population

2000 individuals free of ASCVD and T2D at baseline

Comparison

Different obesity-related anthropometric and dysfunctional adipose tissue-related indices

Design

Cohort study

Follow-up

20 years

Key result

Adiposity indices reflecting total and central adiposity, and adipose tissue dysfunction, were moderately predictive of 20-year incident type 2 diabetes (C-statistic 0.70-0.80).

Authors

IKIoanna KechagiaSGSofia‐Panagiota GiannakopoulouFBFotios Barkas

Discussion

Loading...

Member takes

Overview

Adiposity indices may flag long-term T2D risk in healthy adults; leaves open added predictive value beyond established factors.

Key Points

  • This research evaluates how different indices of body fat are linked to the 20-year risk of developing type 2 diabetes.
  • Included 2000 individuals, free from T2D and ASCVD at baseline.
  • Collected sociodemographic, anthropometric, lifestyle, clinical, and biochemical data at baseline and follow-up.
  • Measured total and central adiposity and dysfunctional adipose tissue-related indices.
  • The cumulative incidence of type 2 diabetes after 20 years was 26.3% (95% CI [24.4%, 28.3%]).
  • All adiposity indices were independently associated with T2D incidence, with an overall predictive accuracy of approximately 75%.
  • Indices reflected adipose tissue dysfunction had moderate discriminative accuracy (C-statistic 0.70-0.80) for predicting T2D.

Study Design

Type

Cohort (n=2,000)

Structured PICO

Do obesity-related anthropometric and dysfunctional adipose tissue-related indices predict the 20-year cumulative incidence of type 2 diabetes in apparently healthy adults?

P
Population
2,000 apparently healthy adults free of atherosclerotic cardiovascular disease and type 2 diabetes at baseline, followed for 20 years.
E
Exposure
Obesity-related anthropometric indices (total and central adiposity) and dysfunctional adipose tissue-related indices
O
Outcome
20-year cumulative incidence of type 2 diabetes (T2D)hard clinical

Obesity-related anthropometric and dysfunctional adipose tissue-related indices are moderately predictive of long-term type 2 diabetes onset over 20 years.

Cite This Study

Kechagia et al. (2026) conducted a cohort in Type 2 diabetes (n=2,000). Adiposity indices was evaluated on 20-year cumulative incidence of type 2 diabetes (T2D). Adiposity indices reflecting total and central adiposity, and adipose tissue dysfunction, were moderately predictive of 20-year incident type 2 diabetes (C-statistic 0.70-0.80).

synapsesocial.com/papers/6a65a8c9d3aea3239cd78fd2https://doi.org/10.1111/cob.70100
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative analysis of obesity indices in discrimination and reclassification of cardiovascular disease risk: The ATTICA study (2002–2022)2025 · 2 citations
  2. 22254-P: Comparing Seven Adiposity Indexes in Their Ability to Predict Type 2 Diabetes Risk across Five U.S. Cohorts2026
  3. 3Association between novel obesity- and lipid-related indices and diabetes across different FBG among elderly: a prospective cohort study2026
  4. 4Adipose tissue biomarkers and type 2 diabetes incidence in normoglycemic participants in the MESArthritis Ancillary Study: A cohort study2021 · 12 citations
  5. 5Anthropometric indices as predictors of type 2 diabetes in a 10-year cohort study from the Yazd Healthy Heart Project2026