Key result
A 1-standard deviation increment in the intermuscular adipose tissue index at baseline was associated with an increased risk of type 2 diabetes incidence (HR 1.27) in normoglycemic adults.
Why the study?
Deposition of adipose tissue beneath muscle fascia rather than subcutaneously may precede insulin resistance and type 2 diabetes, prompting investigation into whether CT-derived adipose tissue biomarkers associate with incident diabetes in normoglycemic adults.
Does higher baseline intermuscular adipose tissue (IMAT) increase the incidence of type 2 diabetes in normoglycemic adults?
Population
1,744 normoglycemic MESA participants from 6 US communities
Comparison
Baseline CT-derived intermuscular adipose tissue (IMAT) index vs subcutaneous adipose tissue (SAT) index
Design
Population-based multiethnic retrospective cohort study
Follow-up
Median 7 years
Authors
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IMAT deposition may flag higher T2D risk; leaves open causal role and need for intervention trials.
Cohort (n=1,744)
Yes
Does higher baseline intermuscular adipose tissue (IMAT) increase the incidence of type 2 diabetes in normoglycemic adults?
Hazard Ratio: 1.27 (95% CI 1.15–1.41)
p-value: p=<0.001
Higher baseline intermuscular adipose tissue (IMAT) is independently associated with an increased risk of developing type 2 diabetes in normoglycemic adults, suggesting ectopic fat deposition precedes clinical insulin resistance.
Pishgar et al. (2021) conducted a cohort in Type 2 diabetes (n=1,744). Intermuscular adipose tissue (IMAT) index vs. Lower IMAT index was evaluated on Type 2 diabetes incidence (HR 1.27, 95% CI 1.15-1.41, p=<0.001). A 1-standard deviation increment in the intermuscular adipose tissue index at baseline was associated with an increased risk of type 2 diabetes incidence (HR 1.27) in normoglycemic adults.
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