Key result
In stroke patients with atrial fibrillation, a lacunar infarct pattern was strongly predicted by a multilacunar state (65% vs 28.9%; OR 7.85, 95% CI 2.45-25.6) and severe white matter lesions.
Why the study?
Does preexisting small vessel disease differ between lacunar and nonlacunar infarct patterns in acute ischemic stroke patients with atrial fibrillation?
Observational (n=231)
Does preexisting small vessel disease differ between lacunar and nonlacunar infarct patterns in acute ischemic stroke patients with atrial fibrillation?
Effect estimate: OR 7.85 (95% CI 2.45-25.6)
Absolute Event Rate: 65% vs 28.9%
p-value: p=0.001
In stroke patients with atrial fibrillation, acute single small deep infarctions are strongly associated with preexisting small vessel disease, suggesting an intrinsic lacunar pathogenesis rather than cardioembolism.
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Suggests SVD contribution to lacunar infarcts in AF stroke; leaves open impact on etiology-specific prevention.
Park et al. (2013) conducted an observational in Acute ischemic stroke with atrial fibrillation (n=231). Lacunar infarct pattern vs. Nonlacunar infarct pattern was evaluated on Multilacunar state (OR 7.85, 95% CI 2.45-25.6, p=0.001). In stroke patients with atrial fibrillation, a lacunar infarct pattern was strongly predicted by a multilacunar state (65% vs 28.9%; OR 7.85, 95% CI 2.45-25.6) and severe white matter lesions.
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