Key result
Quinidine suppresses recurrent refractory polymorphic VT in two post-MI patients.
Why the study?
Post myocardial infarct polymorphic VT triggered by injured Purkinje fibres can cause VT storms refractory to various treatments even after successful reperfusion or revascularization.
Does quinidine prevent refractory polymorphic ventricular tachycardia in post-myocardial infarction patients?
Case Report (n=2)
No
Does quinidine prevent refractory polymorphic ventricular tachycardia in post-myocardial infarction patients?
Quinidine may be a lifesaving treatment for patients with coronary artery disease who develop arrhythmic storms attributable to polymorphic VT that are refractory to standard therapies.
Answers are grounded in this paper and cite their sources.
Quinidine may suppress refractory polymorphic VT post-MI; hypothesis-generating and requires prospective validation before practice change.
Post myocardial infarct polymorphic Ventricular Tachycardia (VT) triggered by injured Purkinje fibres can cause VT storms that are refractory to various treatment even after successful reperfusion or revascularization. We reported such recurrent polymorphic VT in two post myocardial infarct patients after Percutaneous Coronary Intervention. Both of them responded readily to Quinidine. We also discussed the pathophysiology of this arrhythmia and the treatment option of it, namely catheter ablation and antiarrhythmics
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Ng et al. (2023) conducted a case report in Refractory Polymorphic Ventricular Tachycardia (n=2). Quinidine was evaluated on Recurrence of polymorphic ventricular tachycardia. Quinidine successfully suppressed recurrent refractory polymorphic ventricular tachycardia in two post-myocardial infarction patients.
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