Key result
Left atrial enlargement is linked to impaired reservoir function in elderly non-valvular AF patients.
Why the study?
Echocardiographic data on cardiac structure and function in elderly patients with AF and heart failure are limited.
Observational (n=1,494)
Yes
Effect estimate: r=-0.423
p-value: p=<0.0001
In elderly Japanese patients with non-valvular atrial fibrillation, left atrial enlargement is significantly correlated with impaired left atrial reservoir function, particularly in those with a history of heart failure.
LA enlargement was associated with impaired reservoir function in elderly NVAF; hypothesis-generating for risk stratification beyond CHADS2.
BACKGROUND: Echocardiographic data on the cardiac structure and function in elderly patients with atrial fibrillation (AF) and heart failure (HF) are limited. This subcohort study of the ANAFIE Registry analyzed echocardiographic parameters to identify cardiac structural and functional characteristics. METHODS AND RESULTS: score. Types of AF and rhythm were strongly related to LA volume and reservoir function (P<0.0001). Moderate-to-severe mitral and tricuspid regurgitation were significantly more common, and the early diastolic mitral inflow velocity to mitral annulus velocity ratio was significantly higher among patients with than without HF history (all, P<0.0001). CONCLUSIONS: In this subcohort, LA enlargement correlated with impaired LA reservoir function. Elderly patients with non-valvular AF and a history of HF had LA enlargement and dysfunction, increased LV mass index, low LV ejection fraction, and high heart rate.
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Hiasa et al. (2021) conducted an observational in Non-valvular atrial fibrillation (n=1,494). Echocardiographic assessment was evaluated on Correlation between left atrial volume index (LAVi) and left atrial emptying fraction (LAEF) (r=-0.423, p=<0.0001). In elderly patients with non-valvular atrial fibrillation, left atrial enlargement significantly correlated with impaired left atrial reservoir function (r=-0.423), regardless of age and CHADS2 score.
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