Why the study?
Does NIP-142 terminate atrial fibrillation and prolong atrial effective refractory period in canine models?
Population
Canine models of atrial fibrillation and atrial flutter
Design
Review
Authors
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Hypothesis-generating for atrial-selective antiarrhythmics; leaves open translation to human AF therapy.
Does NIP-142 terminate atrial fibrillation and prolong atrial effective refractory period in canine models?
NIP-142 demonstrates atrial-specific prolongation of the effective refractory period and terminates multiple types of experimentally induced atrial fibrillation in canine models.
Tanaka et al. (2007) studied this question.
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