What question did this study set out to answer?

To assess the occurrence and clinical characteristics of modified varicella following vaccination and determine whether postvaccination antibody titers serve as a surrogate marker of protection.

January 1, 1992The Pediatric Infectious Disease Journal

Modified cases of chickenpox after varicella vaccination

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Authors

CWC. J. WhiteTrinity College Dublin BKBarbara J. KuterChildren's Hospital of Philadelphia ANAngela NgaiMerck & Co., Inc., Rahway, NJ, USA (United States)

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Implication

Clinical trial demonstrates attenuated chickenpox occurs infrequently in vaccinated youth, indicating postvaccination antibody titers serve as a reliable surrogate marker for protection.

Key Points

To assess the occurrence and clinical characteristics of modified varicella following vaccination and determine whether postvaccination antibody titers serve as a surrogate marker of protection.
Administered a single dose of live attenuated varicella vaccine (1000 to 1625 plaque-forming units/dose) to 4,042 healthy children and adolescents aged 12 months to 17 years during clinical trials from 1987 to 1989.
Tracked clinical cases of varicella over a two-year follow-up period and measured 6-week postvaccination glycoprotein-based enzyme-linked immunosorbent assay (gpELISA) titers.
Modified cases of varicella developed in 2.1% of vaccinees in Year 1 and 2.4% in Year 2, with most cases exhibiting attenuated illness characterized by fewer lesions and lower rates of fever (≥100°F).
Higher 6-week gpELISA titers significantly reduced the likelihood of developing varicella (P < 0.0001) and were associated with fewer lesions (P = 0.07 in Year 1; P = 0.02 in Year 2).

Cite This Study

White et al. (1992) studied this question.

synapsesocial.com/papers/6a195c73ff42a97fac58147e https://doi.org/10.1097/00006454-199201000-00006

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Implication

Clinical trial demonstrates attenuated chickenpox occurs infrequently in vaccinated youth, indicating postvaccination antibody titers serve as a reliable surrogate marker for protection.

Modified cases of chickenpox after varicella vaccination

Discussion

Member takes

Implication

Key Points

Cite This Study

Modified cases of chickenpox after varicella vaccination

Discussion

Member takes

Implication

Key Points

Cite This Study

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