What question did this study set out to answer?

To determine the metabolic fate and disposal rate of alanine and assess how acute ethanol administration influences alanine-derived gluconeogenesis.

May 1, 1972The Journal of Clinical Endocrinology & Metabolism

Alanine and Gluconeogenesis in Man: Effect of Ethanol

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Authors

RKRobert A. KreisbergPennsylvania State University ASAlan M. SiegalUnited States Department of Veterans Affairs WOWilliam OwenJohn Radcliffe Hospital

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Implication

Experimental study demonstrates that ethanol suppresses alanine conversion to glucose and reduces plasma alanine in healthy humans, indicating reduced substrate availability impairs gluconeogenesis.

Key Points

To determine the metabolic fate and disposal rate of alanine and assess how acute ethanol administration influences alanine-derived gluconeogenesis.
Administered 50 μCi of L-alanine-U-14C intravenously to 6 healthy volunteers on two separate occasions (control vs. oral ethanol).
Supplied oral ethanol via bonded whiskey (19.6 g followed by 9.8 g one hour later) during the experimental intervention.
Tracked plasma concentrations and radioactivity of alanine, glucose, and lactate to calculate half-lives and isotope recoveries.
Alanine-14C recovery in glucose decreased by 75% under ethanol (from 12.5% ± 0.9% to 3.3% ± 0.5%), while recovery in lactate increased by 250% (from 26.5% ± 3.0% to 70.6% ± 6.7%).
Plasma lactate concentrations rose from 0.98 ± 0.07 mM to 1.58 ± 0.09 mM, with lactate specific activity half-life increasing from 32.7 ± 1.1 min to 42.5 ± 3.7 min.
Circulating plasma alanine decreased by 25% after ethanol intake (from 330 ± 38 μM to 248 ± 14 μM), while alanine disappearance half-life remained unchanged (22.8 ± 1.2 min vs. 23.1 ± 1.8 min).

Cite This Study

Kreisberg et al. (1972) studied this question.

synapsesocial.com/papers/6a195f4eac919e0a4888fe2a https://doi.org/10.1210/jcem-34-5-876

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Implication

Experimental study demonstrates that ethanol suppresses alanine conversion to glucose and reduces plasma alanine in healthy humans, indicating reduced substrate availability impairs gluconeogenesis.

Alanine and Gluconeogenesis in Man: Effect of Ethanol

Discussion

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Implication

Key Points

Cite This Study

Alanine and Gluconeogenesis in Man: Effect of Ethanol

Discussion

Member takes

Implication

Key Points

Cite This Study

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