What question did this study set out to answer?

This study aims to evaluate the diagnostic value of oral alanine loading compared to oral glucose loading in assessing metabolic and hormonal functions.

April 1, 2026Open Access

Pancreatic α- and β-Cell Function and Metabolic Changes during Oral L-Alanine and Glucose Administration: Comparative Studies between Normal, Diabetic and Cirrhotic Subjects

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Authors

THT. HattoriNagoya University Hospital NHNIGISHI HOTTA KOKiyoji OHARANagoya University

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Implication

Comparative studies reveal that oral alanine assists in diagnosing metabolic conditions in diabetic and cirrhotic populations, indicating its clinical utility.

Key Points

This study aims to evaluate the diagnostic value of oral alanine loading compared to oral glucose loading in assessing metabolic and hormonal functions.
Administered 50g of L-alanine orally to normal, diabetic, and cirrhotic subjects.
Compared hormonal and metabolic changes with a 100g oral glucose loading.
Monitored lactate, pyruvate, free fatty acids, and glucagon levels over time.
Lactate and pyruvate increased in normal and cirrhotic subjects during L-alanine loading but not in diabetics.
Alanine administration accelerated ureogenesis without affecting blood glucose.
Glucagon levels rose during L-alanine loading across all groups, notably in cirrhotic subjects.
L-alanine stimulated insulin secretion in diabetics, contrasting with no insulin release from glucose loading.

Cite This Study

Hattori et al. (1989) studied this question.

synapsesocial.com/papers/69cd7e935652765b073a992c https://doi.org/10.18999/nagjms.51.1-4.7

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Implication

Comparative studies reveal that oral alanine assists in diagnosing metabolic conditions in diabetic and cirrhotic populations, indicating its clinical utility.

Pancreatic α- and β-Cell Function and Metabolic Changes during Oral L-Alanine and Glucose Administration: Comparative Studies between Normal, Diabetic and Cirrhotic Subjects

Discussion

Member takes

Implication

Key Points

Cite This Study

Pancreatic α- and β-Cell Function and Metabolic Changes during Oral L-Alanine and Glucose Administration: Comparative Studies between Normal, Diabetic and Cirrhotic Subjects

Discussion

Member takes

Implication

Key Points

Cite This Study

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